What is the odds ratio in epidemiology?

The odds ratio is calculated using the number of case-patients who did or did not have exposure to a factor (such as a particular food) and the number of controls who did or did not have the exposure. The odds ratio tells us how much higher the odds of exposure are among case-patients than among controls.

How do you calculate odds ratio in epidemiology?

In a 2-by-2 table with cells a, b, c, and d (see figure), the odds ratio is odds of the event in the exposure group (a/b) divided by the odds of the event in the control or non-exposure group (c/d). Thus the odds ratio is (a/b) / (c/d) which simplifies to ad/bc.

What is odds vs risk in epidemiology?

Odds is the likelihood of a new case occurring rather than not occurring. It differs from risk in that the denominator does not include the patients with the condition. Ratios (risk, rate and odds) provide a relative effect of an intervention or risk factor.

What does an odds ratio of 1.5 mean?

It means that the odds of a case having had exposure #1 are 1.5 times the odds of its having the baseline exposure. This is not the same as being 1.5 times as probable: odds are not the same as probability (odds of 2:1 against means a probability of 13).

What does a odds ratio OR greater than 1.0 mean?

Greater than 1.0 indicates that the odds of exposure among case-patients are greater than the odds of exposure among controls. The exposure might be a risk factor for the disease. • Less than 1.0 indicates that the odds of exposure among case-patients are lower than the odds of exposure among controls.

NCCMT - URE - Odds Ratios

What does an odds ratio of 2.0 mean?

Here it is in plain language. An OR of 1.2 means there is a 20% increase in the odds of an outcome with a given exposure. An OR of 2 means there is a 100% increase in the odds of an outcome with a given exposure. Or this could be stated that there is a doubling of the odds of the outcome.

Is odds ratio the same as prevalence?

Odds ratio (OR) and risk ratio (RR) are two commonly used measures of association reported in research studies. In cross-sectional studies, the odds ratio is also referred to as the prevalence odds ratio (POR) when prevalent cases are included, and, instead of the RR, the prevalence ratio (PR) is calculated.

Is odds ratio the same as incidence?

The normally used odds ratio from a classical case-control study measures the association between genotype and being diseased. In comparison, under incidence density sampling, the incidence rate ratio measures the association between genotype and becoming diseased.

Why is odds ratio better than relative risk?

When the outcome is not rare in the population, if the odds ratio is used to estimate the relative risk it will overstate the effect of the treatment on the outcome measure. The odds ratio will be greater than the relative risk if the relative risk is greater than one and less than the relative risk otherwise.

What does an odds ratio less than 1 mean?

If a predictor variable in a logistic regression model has an odds ratio less than 1, it means that a one unit increase in that variable is associated with a decrease in the odds of the response variable occurring.

What does an odds ratio of 0.8 mean?

Examples. RR of 0.8 means an RRR of 20% (meaning a 20% reduction in the relative risk of the specified outcome in the treatment group compared with the control group).

What is the difference between odds ratio and likelihood ratio?

The odds ratio is the effect of going from “knowing the test negative” to “knowing it's positive” whereas the likelihood ratio + is the effect of going from an unknown state to knowing the test is +. “Unknown state” is not always well defined so I stick to logistic regression for the diagnostic problem.

What is the purpose of odds ratio?

Odds ratios are used to compare the relative odds of the occurrence of the outcome of interest (e.g. disease or disorder), given exposure to the variable of interest (e.g. health characteristic, aspect of medical history).

How do you choose between relative risk and odds ratio?

The basic difference is that the odds ratio is a ratio of two odds (yep, it's that obvious) whereas the relative risk is a ratio of two probabilities. (The relative risk is also called the risk ratio).

What is an example of odds ratio?

The odds ratio is calculated by dividing the odds of the first group by the odds in the second group. In the case of the worked example, it is the ratio of the odds of lung cancer in smokers divided by the odds of lung cancer in non-smokers: (647/622)/(2/27)=14.04.

Is odds ratio a measure of incidence?

The incidence odds ratio is a very convenient measure of effect with many appealing statistical properties including estimability in a case-control study.

What does an odds ratio of 0.5 mean?

An odds ratio of 0.5 would mean that the exposed group has half, or 50%, of the odds of developing disease as the unexposed group. In other words, the exposure is protective against disease.

What do odds of 1.0 mean?

Probabilities between 0 and 0.5 equal odds less than 1.0. A probability of 0.5 is the same as odds of 1.0. Think of it this way: The probability of flipping a coin to heads is 50%. The odds are “fifty: fifty,” which equals 1.0.

What does an odds ratio of 0.7 mean?

If the Odds ratio is 0.7 then it indicates a protective effect - I.e a reduced odds of exposure in case vs control group. That reduced risk is 1-odds so will be 30 percent reduced risk fo exposure. statistical significance is linked to the p-value or CI- which we cannot infer from only the odds ratio.

What is a normal odds ratio?

An odds ratio greater than 1 indicates that the condition or event is more likely to occur in the first group. And an odds ratio less than 1 indicates that the condition or event is less likely to occur in the first group. The odds ratio must be nonnegative if it is defined.

What odds ratio is increased risk?

RELATIVE RISK AND ODDS RATIO

An RR (or OR) more than 1.0 indicates an increase in risk (or odds) among the exposed compared to the unexposed, whereas a RR (or OR) <1.0 indicates a decrease in risk (or odds) in the exposed group.

What does an odds ratio of 0.1 mean?

From probability to odds

So a probability of 0.1, or 10% risk, means that there is a 1 in 10 chance of the event occurring.

Is The odds ratio positive OR negative?

To conclude, the important thing to remember about the odds ratio is that an odds ratio greater than 1 is a positive association (i.e., higher number for the predictor means group 1 in the outcome), and an odds ratio less than 1 is negative association (i.e., higher number for the predictor means group 0 in the outcome ...

What does a negative odds ratio mean?

Positive odds ratios indicate that the event is more likely to occur, whilst negative odd ratios indicate the event is less likely to occur.

What does an odds ratio of 0.00 mean?

If you have an infinite odds in the denominator, then your odds ratio is zero. Finally, if you have a zero odds in the denominator, then your odds ratio is infinite. The only case you can't handle is when both groups have 100% survival or 0% survival.