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What was Ellie's disease up?

The scan in 2008 showed that Ellie's cerebellum in her brain was damaged, causing ataxia. Genetic testing revealed that Ellie had 4H syndrome, a hereditary form of the condition resulting in not just ataxia but also teeth problems and a lack of myelin (nerve insulation) in her brain.
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What illness did Ellie from Up have?

When a doctor finally diagnosed her, the news was grim. Ellie had a rare, neurodegenerative disorder known as LBSL (short for leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation). Doctors gave the family little hope.
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Did Ellie have a miscarriage in Up?

Inspired, they decide to conceive a child and prepare a nursery, but as the music slows, the two learn at the doctor's office that Ellie suffered a miscarriage and they are unable to have children, leaving them devastated. At their house, Carl brings Ellie her childhood scrapbook, which consoles her.
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Why was Ellie immune to the virus?

Ellie's Immunity Comes From Cordyceps Already In Her System

Whenever Cordyceps has entered Ellie's system - such as the bites shown in The Last of Us episodes 2 and 7 - the Cordyceps already in her system make the new fungi entering her body think she is already infected, rendering her immune from its effects.
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Why was Ellie Infected?

Ellie's mother, Anna, had an encounter with an Infected while in labor. In the struggle to kill this Infected, Ellie was born. However, Anna was bitten. Anna quickly cut Ellie's umbilical cord, but not before the Infected reached Ellie.
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Game Theory: Ellie Is NOT Immune! (The Last of Us Part 2)

Why is Ellie immune to Cordyceps?

You see, the leading Firefly theory as to why Ellie is immune to Cordyceps is that the fungal spores inside her body grew up with her. Somehow, probably through that umbilical cord that Anna lied about cutting off before getting bitten, she was exposed to the fungus when she was still a baby.
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Why did Ellie lose two fingers?

her quest for revenge against the person who killed Joel, her adoptive father figure. She is emotionally and physically scarred from the confrontation, having lost the top two joints of the pinky and ring fingers on her left hand in the fight.
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Why can't Ellie forgive Joel?

Here's the long and short of it: Joel was killed before Ellie could forgive him. Her guilt over failing to repair her relationship with the only father figure in her life fuelled her need for revenge, but by not killing Abby, she could forgive Joel through her.
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How does Ellie not infect Dina?

This journal entry and the fact that Ellie also kisses Dina throughout The Last of Us Part II without her turning into a fungal rage monster seems to prove that Ellie's saliva, and therefore her bite, can't spread the Cordyceps infection to others.
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Could Ellie have made a cure?

Joel kills the doctors before they try to synthesize a cure from Ellie's blood, meaning that nobody knows if a cure was actually possible in the HBO show. However, Ellie's immunity to the Infected is never used to make a cure in any of The Last of Us games, with this possibility never being resolved.
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How did Ellie's girlfriend get pregnant?

Background. Near the end of Dina and Jesse's relationship, the two had a sexual encounter that resulted in Dina becoming pregnant with JJ. She revealed her pregnancy to Ellie near the end of their first day in Seattle while they were sheltered inside a theater, thus explaining Dina's recent bouts of sickness.
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How old is Ellie when she dies?

Ellie was one year younger than her husband. If she was still alive, she would have been 78 years old, the same age as Carl.
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What do the balloons symbolize in Up?

The balloons in Up symbolize the wonderment and spirit of childhood. When we first meet Carl, he's a kid toting a balloon with “The Spirit of Adventure” scrawled on it.
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Was Ellie schizophrenic?

It's mentioned a few times that Ellie's mother had schizophrenia; Ellie herself is not diagnosed with any specific mental illness, but the movie does suggest she is experiencing some kind of psychosis, which can include hallucinations.
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How old was Ellie when the infection started?

When Ellie was fourteen, the pair were both infected with the Cordyceps brain infection, where Ellie discovered she was immune.
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Who are Carl and Ellie based on?

Docter felt Grant's personality influenced Carl's deceased wife Ellie more than the grouchy main character, and Carl was primarily based on Spencer Tracy, Walter Matthau, James Whitmore, and their own grandparents, because there was "something sweet about these grumpy old guys".
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Was Ellie's mom immune?

tl;dr Ellie's mom was bitten before Ellie was born, this caused immunity.
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Can Ellie spread the virus?

It is more a case of Ellie's body causing the Cordyceps to mutate into a strain that is non-lethal and does not cause the violent, disease-spreading hosts seen in The Last of Us.
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What killed the Dina?

Here's What Happened the Day the Dinosaurs Died. Sixty-six million years ago, an asteroid struck eastern Mexico and wiped out the dinosaurs. Now scientists have a better idea of what that looked like.
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What was Joel's last words to Ellie?

"I got you, baby girl." In a show full of traumatic episodes, The Last of Us episode 8 may well have been the most traumatic so far.
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What happens to Ellie after Joel dies?

After some time passes where Ellie and the Jackson community mourn Joel's death, Ellie swears revenge on Abby. Tommy tells Ellie he's going to Seattle to find Abby, which motivates Ellie and Dina go off on a journey to Seattle, where the WLF is located.
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What did Joel lie about to Ellie?

He shoots his way through the hospital to rescue her, killing everyone in his path and then lying to Ellie about what really happened by telling her that raiders attacked the hospital. There are others like her, Joel says, but the doctors were unable to find a cure.
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How did Ellie get her eye back?

Ellie was able to purchase an artificial eye to replace the one that she lost; however, she was not able to find one that matched her original eye color.
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Why did Ellie leave Joel's guitar?

The Last of Us: Part 2's guitar is Ellie's last connection to Joel, and even though she'll always have their memories together, leaving the instrument behind is her way of finally saying goodbye.
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Why was Ellie shaking?

Ellie's Right Hand Shakes

This is a common symptom of PTSD, something which Ellie understandably lives with after all the things she has been through. The detail does not really have an effect on gameplay, so one does not have to worry about losing because of it.
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