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When should I get rid of Dragonrot?

Unless you're desperate to complete an NPC's quest, we would hold off curing the disease. Once you have a few Dragon's Blood Droplets to spare, you can occasionally eliminate Dragonrot, but again, you shouldn't need to do so on a regular basis.
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When should I cure Dragonrot?

The time to cure it if you want to conserve then is when you want to chat with an NPC that's sick, and they wont talk due to it. Curing resets the counter to 0, and you will start seeing rot essence pop up again at around 16.
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Should I cure Dragonrot immediately?

If you care about the NPC plotline/quest story, whatever you want to call it, then yeah, cure it. But If you're just playing to enjoy the rest of the game, then curing it is really a waste of your time, since it wastes valuable resources and it's going to come back anyway.
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Does Dragonrot actually matter?

Dragonrot in Sekiro: Shadows Die Twice serves as a kind of punishment for dying and resurrecting too often. Or at least it serves as in incentive not do to it where possible. There is a Dragonrot cure however, helping you mitigate or totally clear away any downsides of the disease - but there's a catch.
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What happens if you have too much Dragonrot?

Dragonrot not only reduces your Unseen Aid by a set percentage, but also prevents NPC questlines from progressing. This is obviously a fairly drastic consequence to death, so try and avoid dying too much in Sekiro – easier said than done.
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Sekiro Shadows Die Twice - How to Heal Dragon rot

Who should I heal Dragonrot?

Curing Dragonrot and losing Rot Essence

After the Sculptor gets sick in the first few hours of Sekiro, you'll find Emma the Physician tending to him. Speak to her, and she'll say that she may be able to create a cure.
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Is Dragonrot a big deal?

It's really not a big deal.

It only takes a single item to clear all of it, and NPC's can't die from it.
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Does Dragonrot spread if you don't resurrect?

Dragonrot is a disease that spreads every time you resurrect in Sekiro: Shadows Die Twice. True to the name of the game, you'll only actually spread this disease if you die twice and resurrect at a Sculptor's Idol.
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Does dying increase Dragonrot?

Dragonrot only increases when you die without resurrecting. If you die, resurrect, and rest, you have no penalty at all.
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Can you beat Sekiro without Dragonrot?

No, you don't have to restart your Sekiro game due to Dragonrot.
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Does Sekiro punish you for dying?

In Sekiro, when you die fully, without resurrecting, you will lose half of the experience and Sen you have earned. Plus, you'll be transported back to the last Sculptor's Idol that you visited, increasing the need to backtrack to where you died. Your EXP & money loss will be permanent.
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Does Dragonrot prevent quests?

Dragonrot(竜咳,Dragon Cough) in Sekiro: Shadows Die Twice affects the NPCs by making them sick, which prevents progression of their Quests. In addition, the more Dragonrot you accumulate, the less Unseen Aid you will have.
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How many deaths does Dragonrot Sekiro have?

Dragonrot will start manifesting after Wolf perishes definitely four times. Some of the characters that interacted with Wolf will become sick and develop a "Rot Essence".
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Are dragon blood droplets limited?

Only 17 Dragon's Blood Droplets can be found organically in each playthrough of Sekiro. Some are found in the world, while others are purchased, but some merchants actually restock on the valuable item. After using a Droplet, Fujioka the Info Broker, as well as both Memorial Mob merchants, will restock on Droplets.
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Why Sekiro is so hard?

The game is easily the most unforgiving experience FromSoftware has ever crafted and is harder than any Souls game simply due to its lack of multiplayer and refusal to compromise. Yet those who conquer Sekiro will never have their skills questioned ever again.
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Why heal Dragonrot?

As we mentioned previously, Dragonrot negatively affects your chances of being granted Unseen Aid when you die. So, you're going to want to cure as many afflicted characters in Sekiro as you can, whenever possible. This is absolutely all the information you need to know about Dragonrot in Sekiro: Shadows Die Twice.
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Should you resurrect in Sekiro?

Most of the time, you're going to want to resurrect given the option. Dying will take half of your money and have of the Skill EXP for your current level. You won't actually lose any Skill Points, but half of any progress to the next one is gone upon death.
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What are the pink circles in Sekiro?

Two pink circles at the bottom left of your screen show Resurrection's availability. As long as at least one circle is full (one refills like a pie chart), you can resurrect. There's a cooldown after you resurrect, so you'll have to wait a few minutes or kill some enemies before you can do it again.
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Can you miss bosses in Sekiro?

Like most of the studio's other titles, Sekiro is home to many missable and/or optional events, bosses, questlines, and NPC characters. Some are more interesting than others, but it's a shame that some players complete the game without knowing they missed out on some incredible experiences.
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Which Sekiro ending is hardest?

In case you are wondering how many endings does Sekiro have, there are actually four. These scale from worst to best as: Shura, Immortal Severance, Purification, and Return. If you want the Sekiro best ending, well, prepare to die (a lot).
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Is Sekiro harder than Dark Souls?

Short answer: Sekiro, which may prove to be one of the most challenging games ever made. Don't just take our word for it—Forbes, Digital Spy, Gamespot and a bevy of other publications agree: Sekiro is harder than any of the Dark Souls games and Bloodborne .
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Do you lose your arm in Sekiro?

We were unable to test this ourselves, but apparently if players beat Genichiro in Sekiro, a slightly different cut-scene plays where Wolf is still defeated and still loses his arm.
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What is missable in Sekiro?

The only thing that can be missed are 2 beads, and that only happens if you do not go for the 2nd best ending where you have to explore the second memory of Owl/Sekiro. There 2 Beads will be dropped from bosses. If you didn't talk to Tengu then Emma will impart the knowledge of the skillbook to you.
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How many endings can you get in Sekiro?

That's even more true considering that Sekiro has not one, not two, but four different endings, each explaining different aspects of the game's lore. Still, fret not, brave shinobi, we've done the homework for you and will tell you exactly what happens in each of Sekiro's endings.
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