Why use C57BL 6 mice?

C57BL/6J mice are resistant to audiogenic seizures, have a relatively low bone density, and develop age related hearing loss. They are also susceptible to diet-induced obesity, type 2 diabetes, and atherosclerosis. Macrophages from this strain are resistant to the effects of anthrax lethal toxin.

Why is C57BL 6 mice used in immunology?

C57BL/6 mice is an inbred mouse strain originally developed for the study of antitumor activity and immunology, and is increasingly being used as an basic background strain. It is known that cell-mediated immunity and NK cell activity are of relatively high importance in determining immunological characteristics.

What is the difference between C57BL 6 and balb c mice?

The Immunological Differences Between C57BL/6 and BALB/c

BALB/c mice tend to produce a stronger humoral response than C57BL/6 mice. These strains have different gene sequences at the H2 site of the major histocompatibility (MHC)class I gene locus - BALB/c mice is H2d, while C57BL/6 is H2b.

What are the disadvantages of C57BL 6 mice?

C57BL/6-derived mice exhibit known phenotypic disadvantages, including sensitivity to pain, addiction, impaired balance, age-dependent hearing loss, and increased anxiety (Mogil et al., 1999; Crawley, 1996; Ouagazzal et al., 2006).

What does C57BL 6 stand for?

C57BL/6, often referred to as "C57 black 6", "C57" or "black 6", is a common inbred strain of laboratory mouse.

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What is difference between C57BL 6J and C57BL 6N?

Two substrains of this mouse strain, C57Bl/6J and C57Bl/6N, are in parallel widely used for research purposes. The two substrains are phenotypically identical but genetically differ by 34 SNPs, two indels and 15 gene variants that overlap a gene.

Are C57BL 6 mice aggressive?

Although some consider C57BL/6 mice to be aggressive, in general they are not when compared to other mouse strains. However, they may appear to be more aggressive because they are the most commonly used mouse strain in research and thus there are many of them to observe.

What are c57 mice used for?

C57BL/6J mice are used in a wide variety of research areas including cardiovascular biology, developmental biology, diabetes and obesity, genetics, immunology, neurobiology, and sensorineural research. C57BL/6J mice are also commonly used in the production of transgenic mice.

What causes death in newborn C57BL 6J mice?

These results suggest that starvation was the most common cause of death, followed by stillbirth.

How long do C57BL 6J mice live?

In well-maintained specific-pathogen-free animals, C57BL/6 mice should live 26-30 months on average. Mice in nature live 3-4 months on average and up to 18 months at the most.

What are the genetic differences among C57BL 6 substrains?

No genetic difference was detected among C57BL/6N substrains. The C57BL/6CrSlc mouse, originally derived from the National Cancer Institute of the NIH was found to be the same as the C57BL/6N substrains by the SNP pattern.

What is il6 in mice?

IL-6 regulates the bone metabolism and inflammatory microenvironment in aging mice by inhibiting Setd7. TH17 cells require ongoing classic IL-6 receptor signaling to retain transcriptional and functional identity.

What are the T cells in C57BL 6 mice?

C57BL/6 CD3 Pan T Cells

CD3 pan T cells from C57BL/6 mice consist of both CD4 and CD8 T cells and make up approximately 33% of cells in the spleen of a typical adult animal.

What is the difference between Swiss albino mice and BALB C mice?

Swiss mice are highly resistant to Leishmania infections in concordance with observed response in humans, while BALB/c mice indicate a high-susceptibility phenotype.

What is the preferred euthanasia of neonatal mice?

Mouse, Rat, and Hamster Neonates up to 10 days of age: Acceptable methods for euthanasia include: injection of chemical anesthetics (e.g., pentobarbital), decapitation or cervical dislocation.

How long are C57BL 6 mice pregnant for?

The gestation period for laboratory mice is generally consistent within a strain but varies among strains. For example, it is 18.5 days in C57BL/6J (000664) mice, 20 days in BALB/cJ (000651) mice, and 21 days in A/J (000646) mice.

Why do mice commit infanticide?

Infanticide has been proposed to be a pathological response to overcrowding or other forms of environmental stress and thus a maladaptive behavior. However, in male house mice this behavior is predictable and is modulated by learning.

What age are c57 mice?

Study-ready aged C57BL/6J males and females are available off-the-shelf between 25 - 90 weeks of age. Aged C57BL/6J mice have research applications that include immunology, cancer, longevity interventions, and biomarker studies.

Do C57BL 6 mice have IgG2a?

Inbred mouse strains, such as BALB/c and Swiss Webster mice, possess the Igh1-a allele, which results in the expression of IgG2a, the gene for IgG2c being absent. Whereas in mouse strains such as C57Bl/6, C57Bl/10, SJL, and NOD mice, the IgG2a gene is deleted.

Why are immunocompromised mice used?

Triple-immunodeficient mice are capable of hosting xenograft cells, tissue, and human immune system components, thus enabling studies of tumor biology and immune-oncology, infectious disease, graft-versus-host disease (GvHD), hematopoiesis, and tissue transplant studies.

Are C57BL 6 mice inbred?

C57BL/6 Mice Details

C57BL/6 mice are the most used inbred strain in research. Our C57BL/6 mouse colonies are genetically identical within each strain, making them free of genetic differences that could impact research results.

What is the fastest killing mice poison?

FASTRAC BLOX with the active ingredient, Bromethalin, is Bell's fastest-acting rodenticide formulation. An acute bait, FASTRAC gets unsurpassed rodent acceptance and control, killing rats and mice in 2 or more days after consuming a toxic dose.

What is the most violent rodent?

Two of the most dangerous and widespread rodents are the black rat — known scientifically as Rattus rattus — and the brown rat — referred to as Rattus norvegicus.